Question for Jane Lyttleton or Leslie Oldershaw

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JennyJohnstonLAc
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Joined: 10/26/2012
Question for Jane Lyttleton or Leslie Oldershaw

In regards to the pituitary-ovary axis, why is it that with poor egg quality you may see a rise in estradiol, leading to low FSH? My understanding is that as follicles mature they release estrogen, and as egg quality reduces and menopause approaches, their ability to produce estrogen goes down, leading to increased FSH. I don't understand the physiology of high Estradiol in poor egg quality and DOR.

Thanks!

Jenny

oldershaw
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Joined: 10/16/2012

Funny thing.

Jenny and I were at a retreat together this weekend, and we discussed this question at length. I actually do not have a good biochemical answer, yet. Great question, though!

oldershaw
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Joined: 10/16/2012

After doing some research online, this is the best description I found of what is going on with DOR, high E2 and low FSH. Great pictures, too.

http://trmbaby.com/media/WebPearlsDec08FSH.pdf

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